OPTIMUM-D

Principal Investigator: Dr. Roumen Milev

This study investigates the biological features of depression and how they can help treatment outcomes in patients. Involves standard antidepressant treatment for 8+ weeks. Participants will complete self-report questionnaires, clinical assessments with a psychiatrist, answer questions about their medical history, bloodwork, electroencephalography (EEG), and more.

You may be eligible to participate in the patient group if you are:

• Between the ages of 18 – 65 years old
• Diagnosed with Major Depressive Disorder and currently feeling depressed
• Able to attend in-person visits at Providence Care Hospital

Still interested in contributing to mental health research but do not have a psychiatric diagnosis?

You may be eligible to participate in the control group if you are:

• Between the ages of 18-65 years old
• No active psychiatric diagnoses
• Able to attend in-person visits at Providence Care Hospital

Email canbind.optimumd@queensu.ca for more information about participation or complete our recruitment survey:

https://redcap.link/join-OPTIMUMD-study

PERFORM-D

Principal Investigator: Dr. Roumen Milev

We are conducting an 18-month observational study on individuals who have recovered from depression.

The purpose of this study is to monitor features such as sleep patterns, cognitive functioning and brain activity to learn more about how relapse happens and what causes it. Participation would include in-person appointments every two months.

You may be eligible to participate if you are:

• Between the ages of 18 – 70 years old
• Diagnosed with Major Depressive Disorder
• Experiencing mild to no depressive symptoms
• Able to attend in-person visits at Providence Care Hospital

Email canbind.optimumd@queensu.ca for more information about participation.

ENABLE

Principal Investigator: Dr. Roumen Milev

This study aims to gather a diverse group of individuals with mood disorders to better understand these conditions and their complexities, and use this information to guide participants toward future study opportunities that they may be eligible for. This study involves one to two visits lasting a total of 5–8 hours, collecting clinical and biological data. Participants will complete self-report questionnaires, clinical assessments, bloodwork, electroencephalography (EEG), and magnetic resonance imaging (MRI).

You may be eligible to participate in the patient group if you are:

• 16 years old or older
• Diagnosed with Bipolar or Depressive Disorders
• Able to attend in-person visits at Providence Care Hospital

Still interested in contributing to mental health research but do not have a psychiatric diagnosis?

You may be eligible to participate in the control group if you are:

• 16 years old or older
• No history of psychiatric diagnoses or significant unstable medical conditions
• Able to attend in-person visits at Providence Care Hospital

Email khanr@providencecare.ca for more information about participation

CBD Study

Principal Investigator: Dr. Roumen Milev

This study is looking to improve depressive symptoms in individuals with bipolar depression. Participants will be randomized to receive either CBD or placebo in addition to their current medications, and psychiatrists will monitor depressive symptoms over a period of 10 weeks. Participation involves 5 in-person visits, including self-report questionnaires, clinical assessments with a psychiatrist, bloodwork, and more.

You may be eligible to participate if you are:

• Between the ages of 19 and 70 years old
• Diagnosed with Bipolar Disorder Type I or Type II, and currently feeling depressed
• Currently taking a mood stabilizing medication (lithium, valproate/epival, risperidone, olanzapine, quetiapine, aripiprazole, ziprasidone, and/or lamotrigine)
• Able to attend in-person visits at Providence Care Hospital

Email cotec@providencecare.ca for more information about participation